WWOX antibody (C-Term)

Catalog No. ABIN5537702

This Rabbit Polyclonal antibody specifically detects WWOX in WB. It exhibits reactivity toward Mouse.

Quick Overview for WWOX antibody (C-Term) (ABIN5537702)

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWOX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WWOX Antibody

Binding Specificity: AA 369-396, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WWOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-396 amino acids from the C-terminal region of human WWOX.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Alternative Name: WWOX

Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90 % identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Molecular Weight: 47 kDa

Gene ID: 51741

UniProt: Q9NZC7