TMED6 antibody (AA 125-153)

Catalog No. ABIN5538213

The Rabbit Polyclonal anti-TMED6 antibody is suitable to detect TMED6 in samples from Human. It has been validated for WB.

Quick Overview for TMED6 antibody (AA 125-153) (ABIN5538213)

Target: TMED6 (Transmembrane Emp24 Protein Transport Domain Containing 6 (TMED6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMED6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TMED6 Antibody

Binding Specificity: AA 125-153

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TMED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human TMED6.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TMED6

Target: TMED6 (Transmembrane Emp24 Protein Transport Domain Containing 6 (TMED6))

Alternative Name: TMED6

Background: TMED6 (transmembrane emp24 domain-containing protein 6) is a 240 amino acid single-pass type I membrane protein that belongs to the EMP24/GP25L family and contains one GOLD domain. The gene that encodes TMED6 contains around 8,564 bases and maps to human chromosome 16q22.1. Encoding over 900 genes and consisting of approximately 90 million base pairs, chromosome 16 makes up nearly 3 % of the human genome and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, when mutated, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Alterations in the CREB gene and NOD2 gene, both of which are located on chromosome 16, result in Rubinstein-Taybi syndrome and Crohn's disease, respectively. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.

Molecular Weight: 28 kDa

Gene ID: 146456

UniProt: Q8WW62