CD40 Ligand antibody (PE)

Catalog No. ABIN5540107

This anti-CD40 Ligand antibody is a Mouse Monoclonal antibody detecting CD40 Ligand in FACS. Suitable for Human and Primate.

Quick Overview for CD40 Ligand antibody (PE) (ABIN5540107)

Target: CD40 Ligand (CD40LG)

Reactivity: Human, Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD40 Ligand antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 24-31

Product Details anti-CD40 Ligand Antibody (PE)

Specificity: This antibody detects CD154 / CD40L (CD40-ligand), a 39 kDa cell surface type II glycoprotein expressed predominantly on activated CD4+ lymphocytes.

Immunogen: Human CD154 fusion protein

Isotype: IgG1

Application Details

Application Notes: Flow cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10 6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD40 Ligand

Target: CD40 Ligand (CD40LG)

Alternative Name: cd154,cd40l

Background: CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.

UniProt: P29965

Pathways: NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints