KCNK2 antibody (AA 4-14)

Catalog No. ABIN5540445

The Rabbit Polyclonal anti-KCNK2 antibody is suitable to detect KCNK2 in samples from Human. It has been validated for WB and EIA.

Quick Overview for KCNK2 antibody (AA 4-14) (ABIN5540445)

Target: KCNK2 (Potassium Channel, Subfamily K, Member 2 (KCNK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-KCNK2 Antibody

Binding Specificity: AA 4-14

Sequence: SASRERPGYT A

Specificity: This antibody reacts with the 47 kDa TREK-1 in Jurkat cell extract.

Purification: Protein G affinity

Immunogen: A synthetic peptide derived from the amino sequence 4-14 of human TREK-1, conjugated with KLH

Application Details

Application Notes: ELISA: The antibody (1:500,000 diluted) can detect the TREK-1 peptide coated on ELISA plate at 100 ng/well. Western blot: Dilute approx. 1:3,000 to detect the 47 kDa TREK-1 in Jurkat cell extract.

Restrictions: For Research Use only

Handling

Buffer: 0.01M PBS, pH 7.4

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for KCNK2

Target: KCNK2 (Potassium Channel, Subfamily K, Member 2 (KCNK2))

Alternative Name: kcnk2

Background: TWIK-related potassium channel 1(TREK-1), also known as K2P2.1, is a two pore domain gated potassium channel that is involved with pain reception. TREK-1 is highly expressed in small sensory neurons and is extensively colocalized with TRPV1. TREK-1 is sensitive to noxious stimuli including extracellular pH , temperature, mechanical force, osmotic pressure and other stimuli. TREK-1 is one of the targets for pain mediator and anaesthesia drug.