VEGFC antibody (Biotin)

Catalog No. ABIN5540708

This Mouse Monoclonal antibody specifically detects VEGFC in EIA. It exhibits reactivity toward Human.

Quick Overview for VEGFC antibody (Biotin) (ABIN5540708)

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VEGFC antibody is conjugated to Biotin

Application: Enzyme Immunoassay (EIA)

Clone: 107-A11

Product Details anti-VEGFC Antibody (Biotin)

Specificity: This antibody recognizes Human VEGF-C. Other species not tested.

Purification: Protein G Chromatography

Immunogen: Recombinant Human VEGF-C (Cat.-No AR01001PU-N)

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1-5 μg/mL.

Restrictions: For Research Use only

Handling

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Alternative Name: vegf-c,flt4-l

Background: VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 115 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.

UniProt: P49767

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2