HINT2 antibody (AA 18-163)

Catalog No. ABIN5540727

The Mouse Monoclonal anti-HINT2 antibody has been validated for WB, FACS and EIA. It is suitable to detect HINT2 in samples from Human.

Quick Overview for HINT2 antibody (AA 18-163) (ABIN5540727)

Target: HINT2 (Histidine Triad Nucleotide Binding Protein 2 (HINT2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HINT2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: AT5B10

Product Details anti-HINT2 Antibody

Binding Specificity: AA 18-163

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human HINT2 (18-163aa) purified from E. coli.

Isotype: IgG1

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot analysis and Flow cytometry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. In Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for HINT2

Target: HINT2 (Histidine Triad Nucleotide Binding Protein 2 (HINT2))

Alternative Name: hint2

Background: Histidine triad nucleotide binding protein 2 (HINT2) is a mitochondrial protein. This protein is an AMP-lysine hydrolase and phosphoamidase and may contribute to tumor suppression. This protein is a member of the HIT superfamily and Hint subfamily, which are characterized as nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides. HINT2 regulates steroidogenesis through calcium-dependent and calcium-independent siglling pathways that may serve to maintain a favorable mitochondrial potential. Its role in calcium homeostasis may also contribute to its proapoptotic function in hepatocytes and other non-steroidogenic cells, though the exact mechanism remains unclear.

UniProt: Q9BX68