BCL2L1 antibody (pThr115)

Catalog No. ABIN5541071

This Rabbit Polyclonal antibody specifically detects BCL2L1 in EIA. It exhibits reactivity toward Human.

Quick Overview for BCL2L1 antibody (pThr115) (ABIN5541071)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Product Details anti-BCL2L1 Antibody

Binding Specificity: pThr115

Sequence: TSQLHITpPG TAY

Specificity: This antibody detects Human and other species with consensus Bcl-xL peptide (TSQLHITpPGTAY).

Purification: Protein G affinity

Immunogen: A synthetic peptide derived from Threonine 115 phosphorylated Bcl-xL, conjugated with KLH

Application Details

Application Notes: ELISA: The antibody, when 1:10,000 1:100,000 diluted, can detect the Threonine 115 phosphorylated Bcl-xL coated on ELISA plate.

Restrictions: For Research Use only

Handling

Buffer: 0.01M PBS, pH 7.4

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Alternative Name: bcl-2-like 1

Background: Bcl-xL is a prosurvival factor in the Bcl-2 family. It is a mitochondrial outer membrane protein that regulates the voltage-dependent anion channels (VDAC), and controls the production of reactive oxygen species and the release of cytochrome C. Bcl-xL gene knock-out resulted in embryonic lethality in animal model due to neuronal apoptosis and erythroid apoptosis. Bcl-xL is believed to be involved with the survival and differentiation of erythroid cells, iron metabolism and hemoglobin synthesis.

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling