CCRL2 antibody

Catalog No. ABIN5541108

The Mouse Monoclonal anti-CCRL2 antibody has been validated for IHC (p). It is suitable to detect CCRL2 in samples from Human.

Quick Overview for CCRL2 antibody (ABIN5541108)

Target: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCRL2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1B2

Product Details anti-CCRL2 Antibody

Specificity: This antibody detects human CCRL2.

Purification: Protein G

Immunogen: DNA vaccine

Isotype: IgG2a

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 4-8 μg/mL (1/50-1/100). Positive control: Human placenta.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CCRL2

Target: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Alternative Name: ccrl2,ccr11

Background: Lipopolysaccharide-inducible CC chemokine receptor (LCCR), or CCRL2 is a 344 amino acid protein that belongs to the G - protein coupled receptor 1 family, with a potential glycosylation site and one disulfide bond. CCRL2 is e xp ressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow, but also in lung and heart. CCRL2 is e xpressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T - cells (both CD4+ and CD8+), monocyte - de rived iDCs, NK cells, and CD34+ progenitor cells, and also on glial cells and mast cells at inflammatory sites. It has been reported to be up - regulated on synovial neutrophils of rheumatoid arthritis patients. Unlike other known G - protein coupled receptors, binding of an agonist such as CCL5 or CCL19 does not induce signal transduction through CCRL2. Rather, the ligand is absorbed after binding, and the receptor recycled, thus reducing the local ligand concentration. The leukocyte chemoattractant chemerin is a ligand for CCRL2 as well, but rather than being recycled, the complex seems to promote bridging to the chemerin receptor on nearby cells.

UniProt: O00421