IKZF2 antibody (AA 51-107)

Catalog No. ABIN5541430

This anti-IKZF2 antibody is a Hamster Monoclonal antibody detecting IKZF2 in FACS. Suitable for Human and Mouse.

Quick Overview for IKZF2 antibody (AA 51-107) (ABIN5541430)

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Reactivity: Human, Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This IKZF2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 22F6

Product Details anti-IKZF2 Antibody

Binding Specificity: AA 51-107

Specificity: This antibody recognizes Helios, a transcription factor expressed in some hematopoietic stem cells, and at high levels in thymic-derived regulatory T cells.

Purification: Protein-A affinity chromatography

Immunogen: Peptide coresponding to the amino acids 51-107 of Helios

Isotype: IgG

Application Details

Application Notes: Flow cytometry: Intracellular staining.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered saline (PBS) Preservatives: 15 mM sodium azide, approx. pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for IKZF2

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Alternative Name: znfn1a2 (ikzf2, helios)

Background: Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells.

UniProt: Q9UKS7