IKZF2 antibody (AA 51-107) (PE)

Catalog No. ABIN5541431

This Hamster Monoclonal antibody specifically detects IKZF2 in FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for IKZF2 antibody (AA 51-107) (PE) (ABIN5541431)

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Reactivity: Human, Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This IKZF2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 22F6

Product Details anti-IKZF2 Antibody (PE)

Binding Specificity: AA 51-107

Specificity: This antibody recognizes Helios, a transcription factor expressed in some hematopoietic stem cells, and at high levels in thymic-derived regulatory T cells.

Immunogen: Peptide coresponding to the amino acids 51-107 of Helios

Isotype: IgG

Application Details

Application Notes: Flow cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10 6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for IKZF2

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Alternative Name: znfn1a2 (ikzf2, helios)

Background: Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells.

UniProt: Q9UKS7