ACOX1 antibody

Catalog No. ABIN5541563

This Mouse Monoclonal antibody specifically detects ACOX1 in WB, IF, ICC and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ACOX1 antibody (ABIN5541563)

Target: ACOX1 (Acyl-CoA Oxidase 1, Palmitoyl (ACOX1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACOX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 153CT43-1-1

Product Details anti-ACOX1 Antibody

Specificity: This antibody recognizes Human ACOX1. Other species not tested.

Purification: Protein G Chromatography, followed by dialysis against PBS

Immunogen: ACOX1 recombinant protein.

Isotype: IgG1

Application Details

Application Notes: Western blot: 1/100-1/500. Immunofluorescence: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/10-1/50.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS Preservatives: 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for ACOX1

Target: ACOX1 (Acyl-CoA Oxidase 1, Palmitoyl (ACOX1))

Alternative Name: acox1

Background: ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Function: Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25 % more active against 1,16-hexadecanodioyl- CoA. Cellular Location: Peroxisome. Tissue Location: Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.

UniProt: Q15067

Pathways: Regulation of Lipid Metabolism by PPARalpha, Monocarboxylic Acid Catabolic Process