LGR4 antibody

Catalog No. ABIN5541954

The Rat Monoclonal anti-LGR4 antibody has been validated for FACS and EIA. It is suitable to detect LGR4 in samples from Human and Mouse.

Quick Overview for LGR4 antibody (ABIN5541954)

Target: LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This LGR4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: BBX-3A8

Product Details anti-LGR4 Antibody

Specificity: Recognizes LGR4 / GPR48. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.

Purification: Affinity Chromatography on Protein G

Immunogen: cDNA encoding Human LGR4

Isotype: IgG2a

Application Details

Application Notes: Flow cytometry: 1.2 μg/10 6 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.2

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for LGR4

Target: LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))

Alternative Name: lgr4,gpr48

Background: LGR4 (Leucine-rich repeat- containing G protein-coupled receptor 4) belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 951 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains (1,3). LGR4 is highly expressed in the adult human pancreas but also with moderate levels of expression in placenta, kidney, brain and heart (2). LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. It is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression.

UniProt: Q9BXB1