CR1L antibody

Catalog No. ABIN5542182

The Rat Monoclonal anti-CR1L antibody has been validated for EIA. It is suitable to detect CR1L in samples from Mouse.

Quick Overview for CR1L antibody (ABIN5542182)

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CR1L antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: 8A-E6

Product Details anti-CR1L Antibody

Specificity: The monoclonal antibody 8A/E6 recognizes Mouse complement receptor type-1 related gene Y (Crry/p65), a type I membrane protein (MW 56-60 kDa).

Purification: Purified

Immunogen: Mouse Crry fused to Mouse IgG2a-Fc

Isotype: IgG1

Application Details

Application Notes: Immuno assays.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CR1L

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Alternative Name: cr1l,crry

Background: Complement comprises a system of soluble serum proteins that, upon activation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Rat and mouse express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). Crry/p65 is expressed on a wide variety of cells. Crry/p65 contains tandem short consensus repeats (SCR) characteristic of C3/C4 binding proteins. Mouse Crry/p65 has been shown to regulate both classical and alternative complement pathway C3 deposition on cell membranes. Crry/p65 must, therefore, exert its effects prior to, or at the level of, the C3 convertases, in a fashion similar to that of the human membrane factors DAF and MCP. Crry/p65 is an evolutionarily unique, complement regulatory protein which has developed in mouse and rat. Besides the involvement in control of complement damage to cell membranes Crry has also a role in T cell activation. Crry basically enhances the signals triggered by TCR/CD3 activation.

UniProt: Q64735

Pathways: Complement System