alpha Adducin antibody (AA 1-193)

Catalog No. ABIN5542416

The Mouse Monoclonal anti-alpha Adducin antibody has been validated for IHC and ELISA. It is suitable to detect alpha Adducin in samples from Human.

Quick Overview for alpha Adducin antibody (AA 1-193) (ABIN5542416)

Target: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This alpha Adducin antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 5D4H1

Product Details anti-alpha Adducin Antibody

Binding Specificity: AA 1-193

Purpose: ADD1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human ADD1 (AA: 1-193) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for alpha Adducin

Target: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Alternative Name: ADD1

Background: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms, however, not all variants have been fully described.

Molecular Weight: 81 kDa

Gene ID: 118

UniProt: P35611

Pathways: Negative Regulation of Hormone Secretion, Regulation of Actin Filament Polymerization, Regulation of Lipid Metabolism by PPARalpha, ER-Nucleus Signaling