RAP1GAP antibody (AA 412-660)

Catalog No. ABIN5542476

The Mouse Monoclonal anti-RAP1GAP antibody has been validated for ELISA and FACS. It is suitable to detect RAP1GAP in samples from Human.

Quick Overview for RAP1GAP antibody (AA 412-660) (ABIN5542476)

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAP1GAP antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 2G7B6

Product Details anti-RAP1GAP Antibody

Binding Specificity: AA 412-660

Purpose: RAP1GAP Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human RAP1GAP (AA: 412-660) expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for RAP1GAP

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Alternative Name: RAP1GAP

Background: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Molecular Weight: 73.4 kDa

UniProt: P47736