SSH1 antibody (AA 1032-1044)

Catalog No. ABIN5542669

Product Details anti-SSH1 Antibody

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Binding Specificity: AA 1032-1044

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SSH1 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: SLINGSHOT-1L Antibody

Purification: Purified antibody

Immunogen: Synthesized peptide fragment of human SLINGSHOT-1L (AA: 1032-1044 ) expressed in E. Coli.

Clone: 1A5C8

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for SSH1

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Alternative Name: SLINGSHOT-1L (SSH1 Products)

Background: The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 115.5 kDa

Gene ID: 54434

UniProt: Q8WYL5

Pathways: CXCR4-mediated Signaling Events