Complement C3c antibody (AA 1521-1649)

Catalog No. ABIN5542705

Product Details anti-Complement C3c Antibody

Target: Complement C3c (C3C) (Complement Component C3c (C3C))

Binding Specificity: AA 1521-1649

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Complement C3c antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: C3C Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human C3C (AA: 1521-1649) expressed in E. Coli.

Clone: 8B5H2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Complement C3c antibody (ABIN5542705)

Helsby, Leader, Fenn, Gulsen, Bryant, Doughton, Sharpe, Whitley, Caunt, James, Pope, Kelly, Chalmers: "CiteAb: a searchable antibody database that ranks antibodies by the number of times they have been cited." in: BMC cell biology, Vol. 15, pp. 6, (2014) (PubMed).

Target Details for Complement C3c

Target: Complement C3c (C3C) (Complement Component C3c (C3C))

Alternative Name: C3C (C3C Products)

Background: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.

Molecular Weight: 187.1 kDa

Gene ID: 718

UniProt: P01024