DOC2A antibody (AA 652-749)

Catalog No. ABIN5542714

This anti-DOC2A antibody is a Mouse Monoclonal antibody detecting DOC2A in ELISA, FACS and ICC. Suitable for Human.

Quick Overview for DOC2A antibody (AA 652-749) (ABIN5542714)

Target: DOC2A (Double C2-Like Domains, alpha (DOC2A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DOC2A antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 2H7C4

Product Details anti-DOC2A Antibody

Binding Specificity: AA 652-749

Purpose: DOC2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human DOC2 (AA: 652-749) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for DOC2A

Target: DOC2A (Double C2-Like Domains, alpha (DOC2A))

Alternative Name: DOC2

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 82.4 kDa

UniProt: P98082

Pathways: Synaptic Vesicle Exocytosis