IL1F9 antibody

Catalog No. ABIN5564239

This anti-IL1F9 antibody is a Mouse Monoclonal antibody detecting IL1F9 in WB and ELISA. Suitable for Human.

Quick Overview for IL1F9 antibody (ABIN5564239)

Target: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1F9 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: Jussy-1

Product Details anti-IL1F9 Antibody

Specificity: Recognizes human IL-36gamma.

Cross-Reactivity: Human

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human IL-36gamma.

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for IL1F9

Target: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Alternative Name: IL-36gamma

Background: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.