FIL1h antibody

Catalog No. ABIN5564285

This Mouse Monoclonal antibody specifically detects FIL1h in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for FIL1h antibody (ABIN5564285)

Target: FIL1h (Interleukin 1 eta (FIL1h))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FIL1h antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: Jacky-1

Product Details anti-FIL1h Antibody

Specificity: Recognizes human IL-36beta.

Cross-Reactivity: Human

No Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Does not cross-react with mouse IL-36beta and IL-36gamma.

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human IL-36beta.

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for FIL1h

Target: FIL1h (Interleukin 1 eta (FIL1h))

Alternative Name: IL-36beta

Background: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.