CTH antibody (AA 1-405)

Catalog No. ABIN560521

This Mouse Monoclonal antibody specifically detects CTH in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 21+ publications.

Quick Overview for CTH antibody (AA 1-405) (ABIN560521)

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTH antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 4E1-1B7

Product Details anti-CTH Antibody

Binding Specificity: AA 1-405

Purpose: Mouse monoclonal antibody raised against a full length recombinant CTH.

Sequence: MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGRSDV VMGLVSVNCE SLHNRLRFLQ NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS

Cross-Reactivity: Guinea Pig, Human, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CTH (AAH15807, 1 a.a. ~ 405 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CTH antibody (ABIN560521)

Li, Li, Du, Wang, You, Wang, Xu, Cheng, Cao, Liu, Hu: "Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter." in: International journal of molecular sciences, Vol. 16, Issue 6, pp. 12560-77, (2015) (PubMed).

Xu, Du, Li, Xu, Wang, You, Liu, Wang, Cao, Liu, Hu: "Statins upregulate cystathionine ?-lyase transcription and H2S generation via activating Akt signaling in macrophage." in: Pharmacological research : the official journal of the Italian Pharmacological Society, Vol. 87, pp. 18-25, (2014) (PubMed).

Ida, Sawa, Ihara, Tsuchiya, Watanabe, Kumagai, Suematsu, Motohashi, Fujii, Matsunaga, Yamamoto, Ono, Devarie-Baez, Xian, Fukuto, Akaike: "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 21, pp. 7606-11, (2014) (PubMed).

Yang, Zhao, Ju, Mani, Cao, Puukila, Khaper, Wu, Wang: "Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2." in: Antioxidants & redox signaling, Vol. 18, Issue 15, pp. 1906-19, (2013) (PubMed).

Mani, Li, Untereiner, Wu, Yang, Austin, Dickhout, Lhoták, Meng, Wang: "Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis." in: Circulation, Vol. 127, Issue 25, pp. 2523-34, (2013) (PubMed).

Badiei, Rivers-Auty, Ang, Bhatia: "Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells." in: Applied microbiology and biotechnology, Vol. 97, Issue 17, pp. 7845-52, (2013) (PubMed).

Kasparek, Linden, Farrugia, Sarr: "Hydrogen sulfide modulates contractile function in rat jejunum." in: The Journal of surgical research, Vol. 175, Issue 2, pp. 234-42, (2012) (PubMed).

Yang, Pei, Cao, Wang: "MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells." in: Journal of cellular physiology, Vol. 227, Issue 9, pp. 3192-200, (2012) (PubMed).

Yang, Li, Tang, Wu, Zhao, Cao, Xu, Wang: "Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in ?5?1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells." in: Journal of molecular and cellular cardiology, Vol. 52, Issue 3, pp. 677-88, (2012) (PubMed).

Dufton, Natividad, Verdu, Wallace: "Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe." in: Scientific reports, Vol. 2, pp. 499, (2012) (PubMed).

Wu, Teng, Yang, Wu, Wang: "Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1?." in: British journal of pharmacology, Vol. 167, Issue 7, pp. 1492-505, (2012) (PubMed).

Fu, Zhang, Yang, Wang: "Is cystathionine gamma-lyase protein expressed in the heart?" in: Biochemical and biophysical research communications, Vol. 428, Issue 4, pp. 469-74, (2012) (PubMed).

Holwerda, Bos, Rajakumar, Ris-Stalpers, van Pampus, Timmer, Erwich, Faas, van Goor, Lely: "Hydrogen sulfide producing enzymes in pregnancy and preeclampsia." in: Placenta, Vol. 33, Issue 6, pp. 518-21, (2012) (PubMed).

Yang, Pei, Teng, Cao, Wang: "Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells." in: The Journal of biological chemistry, Vol. 286, Issue 30, pp. 26450-60, (2011) (PubMed).

Li, Mao, Hei, Zhang, Wen, Zhang, Qiu, Qiao: "Protective role of hydrogen sulfide against noise-induced cochlear damage: a chronic intracochlear infusion model." in: PLoS ONE, Vol. 6, Issue 10, pp. e26728, (2011) (PubMed).

Martin, McKnight, Dicay, Coffin, Ferraz, Wallace: "Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract." in: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, Vol. 42, Issue 2, pp. 103-9, (2010) (PubMed).

Feng, Chen, Zhao, Tang, Jiang, Geng: "Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator." in: Biochemical and biophysical research communications, Vol. 380, Issue 1, pp. 153-9, (2009) (PubMed).

Wallace, Vong, McKnight, Dicay, Martin: "Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats." in: Gastroenterology, Vol. 137, Issue 2, pp. 569-78, 578.e1, (2009) (PubMed).

Fu, Liu, Geng, Fang, Tang: "Hydrogen sulfide protects rat lung from ischemia-reperfusion injury." in: Life sciences, Vol. 82, Issue 23-24, pp. 1196-202, (2008) (PubMed).

Wallace, Dicay, McKnight, Martin: "Hydrogen sulfide enhances ulcer healing in rats." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 21, Issue 14, pp. 4070-6, (2007) (PubMed).

Target Details for CTH

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Alternative Name: CTH

Background: Full Gene Name: cystathionase (cystathionine gamma-lyase)
Synonyms: MGC9471

Gene ID: 1491

Pathways: ER-Nucleus Signaling, Warburg Effect