CTH antibody (AA 1-405)

Catalog No. ABIN560522

There are 5+ publications for this product available. The Mouse Monoclonal anti-CTH antibody is suitable to detect CTH in samples from Human. It has been validated for WB and ELISA.

Quick Overview for CTH antibody (AA 1-405) (ABIN560522)

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTH antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2E12-1C10

Product Details anti-CTH Antibody

Binding Specificity: AA 1-405

Purpose: Mouse monoclonal antibody raised against a full length recombinant CTH.

Sequence: MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGRSDV VMGLVSVNCE SLHNRLRFLQ NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CTH (AAH15807, 1 a.a. ~ 405 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CTH antibody (ABIN560522)

Grassi, Tyagi, Calvert, Gambari, Walker, Yu, Robinson, Li, Lisignoli, Vaccaro, Adams, Pacifici: "Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 5, pp. 949-63, (2016) (PubMed).

Dickhout, Carlisle, Jerome, Mohammed-Ali, Jiang, Yang, Mani, Garg, Banerjee, Kaufman, Maclean, Wang, Austin: "Integrated stress response modulates cellular redox state via induction of cystathionine ?-lyase: cross-talk between integrated stress response and thiol metabolism." in: The Journal of biological chemistry, Vol. 287, Issue 10, pp. 7603-14, (2012) (PubMed).

Maclean, Sikora, Kožich, Jiang, Greiner, Kraus, Krijt, Overdier, Collard, Brodsky, Meltesen, Crnic, Allen, Stabler, Elleder, Rozen, Patterson, Kraus: "A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment." in: Molecular genetics and metabolism, Vol. 101, Issue 2-3, pp. 153-62, (2010) (PubMed).

dEmmanuele di Villa Bianca, Sorrentino, Maffia, Mirone, Imbimbo, Fusco, De Palma, Ignarro, Cirino: "Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 11, pp. 4513-8, (2009) (PubMed).

Zhang, Jiang, Fang, Yan, Song, Gupta, Schafer, Durante, Kruger, Yang, Wang: "Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice." in: Circulation, Vol. 120, Issue 19, pp. 1893-902, (2009) (PubMed).

Target Details for CTH

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Alternative Name: CTH

Background: Full Gene Name: cystathionase (cystathionine gamma-lyase)
Synonyms: MGC9471

Gene ID: 1491

Pathways: ER-Nucleus Signaling, Warburg Effect