CD137 antibody (AA 24-186)

Catalog No. ABIN5611112

Product Details anti-CD137 Antibody

Target: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Binding Specificity: AA 24-186

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD137 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: CD137 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD137 (AA: 24-186) expressed in E. Coli.

Clone: 4G10B9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for CD137

Target: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Alternative Name: CD137 (TNFRSF9 Products)

Background:

Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Aliases: TNFRSF9, ILA, 4-1BB, CDw137

Molecular Weight: 27.9kDa

Gene ID: 3604

HGNC: 3604

UniProt: Q07011

Pathways: Cancer Immune Checkpoints