GRK6 antibody (AA 71-170)

Catalog No. ABIN561115

This Mouse Monoclonal antibody specifically detects GRK6 in WB and ELISA. It exhibits reactivity toward Human.It has been mentioned in 1 publication

Quick Overview for GRK6 antibody (AA 71-170) (ABIN561115)

Target: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GRK6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 8D4

Product Details anti-GRK6 Antibody

Binding Specificity: AA 71-170

Purpose: Mouse monoclonal antibody raised against a partial recombinant GRK6.

Sequence: CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: GRK6 (AAH17272, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-GRK6 antibody (ABIN561115)

McCormick, Segarra, Gasperini, Gulino, Tosato: "Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor." in: PLoS ONE, Vol. 4, Issue 12, pp. e8102, (2009) (PubMed).

Target Details for GRK6

Target: GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))

Alternative Name: GRK6

Background: Full Gene Name: G protein-coupled receptor kinase 6
Synonyms: FLJ32135,GPRK6

Gene ID: 2870

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Negative Regulation of Transporter Activity