GRM7 antibody (AA 454-590)

Catalog No. ABIN5611161

The Mouse Monoclonal anti-GRM7 antibody has been validated for ELISA, FACS and ICC. It is suitable to detect GRM7 in samples from Human.

Quick Overview for GRM7 antibody (AA 454-590) (ABIN5611161)

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GRM7 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 7G8D3

Product Details anti-GRM7 Antibody

Binding Specificity: AA 454-590

Purpose: GRM7 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for GRM7

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Alternative Name: GRM7

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 102.3 kDa

Gene ID: 2917

UniProt: Q14831

Pathways: Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour