Metabotropic Glutamate Receptor 3 antibody (AA 433-576)

Catalog No. ABIN5611177

This anti-Metabotropic Glutamate Receptor 3 antibody is a Mouse Monoclonal antibody detecting Metabotropic Glutamate Receptor 3 in ELISA, IHC, FACS and ICC. Suitable for Human.

Quick Overview for Metabotropic Glutamate Receptor 3 antibody (AA 433-576) (ABIN5611177)

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Metabotropic Glutamate Receptor 3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 7A5A6

Product Details anti-Metabotropic Glutamate Receptor 3 Antibody

Binding Specificity: AA 433-576

Purpose: GRM3 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human GRM3 (AA: 433-576) expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Metabotropic Glutamate Receptor 3

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Alternative Name: GRM3

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Molecular Weight: 99 kDa

Gene ID: 2913

UniProt: Q14832

Pathways: cAMP Metabolic Process, Synaptic Membrane