BAK1 antibody (AA 29-187)

Catalog No. ABIN5611250

Product Details anti-BAK1 Antibody

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Binding Specificity: AA 29-187

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: BAK1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human BAK1 (AA: 29-187) expressed in E. Coli.

Clone: 2H9H7

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for BAK1

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Alternative Name: BAK1 (BAK1 Products)

Background:

Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Aliases: BAK, CDN1, BCL2L7, BAK-LIKE

Molecular Weight: 23.4kDa

Gene ID: 578

HGNC: 578

UniProt: Q16611

Pathways: Apoptosis, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response