Estrogen Receptor alpha antibody (Estrogen Receptor 1) (AA 530-542)

Details for Product anti-ESR1 Antibody No. ABIN5611310
Target
Binding Specificity
AA 530-542
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31
29
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21
18
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13
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3
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3
3
2
2
2
2
2
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
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Reactivity
Human
593
255
206
40
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10
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5
5
4
3
3
1
1
Host
Mouse
453
176
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
42
24
24
17
16
13
12
12
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12
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11
6
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4
4
4
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4
4
4
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4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
445
211
206
143
103
80
78
55
54
18
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2
1
1
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Options
Immunogen Synthesized peptide of human Eralpha(AA 530-542 (Tyr-537) expressed in E. Coli.
Clone 3C6C6
Isotype IgG1
Target
Alternative Name Eralpha (ESR1 Antibody Abstract)
Background This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.,
Molecular Weight 66.2kDa
HGNC 2099
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Application Notes ELISA: 1:10000, WB: , IHC: , ICC: , FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Images
Image no. 1 for anti-Estrogen Receptor 1 (ESR1) (AA 530-542) antibody (ABIN5611310) Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen ...
Image no. 2 for anti-Estrogen Receptor 1 (ESR1) (AA 530-542) antibody (ABIN5611310) Flow cytometric analysis of HeLa cells using Eralpha(Tyr-537) mouse mAb (green) and n...