PVRL2 antibody (AA 58-212)

Catalog No. ABIN5611344

The Mouse Monoclonal anti-PVRL2 antibody has been validated for FACS and ELISA. It is suitable to detect PVRL2 in samples from Human.

Quick Overview for PVRL2 antibody (AA 58-212) (ABIN5611344)

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PVRL2 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: 4A11B12

Product Details anti-PVRL2 Antibody

Binding Specificity: AA 58-212

Purpose: CD112 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD112 (AA: 58-212) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Alternative Name: CD112

Background: This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Molecular Weight: 57.7 kDa

Gene ID: 5819

UniProt: Q92692

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization