SPINK1 antibody (AA 24-79)

Catalog No. ABIN562978

This Mouse Monoclonal antibody specifically detects SPINK1 in WB, ELISA, IHC (p) and IP. It exhibits reactivity toward Human. It has been mentioned in 8+ publications

Quick Overview for SPINK1 antibody (AA 24-79) (ABIN562978)

Target: SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SPINK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Clone: 4D4

Product Details anti-SPINK1 Antibody

Binding Specificity: AA 24-79

Purpose: Mouse monoclonal antibody raised against a partial recombinant SPINK1.

Sequence: DSLGREAKCY NELNGCTKIY DPVCGTDGNT YPNECVLCFE NRKRQTSILI QKSGPC

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: SPINK1 (AAH25790, 24 a.a. ~ 79 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-SPINK1 antibody (ABIN562978)

Palanisamy, Tsodikov, Yan, Suleman, Rittmaster, Lucia, Chinnaiyan, Fleshner, Kunju: "Molecular profiling of ETS gene rearrangements in patients with prostate cancer registered in REDEEM clinical trial." in: Urologic oncology, Vol. 33, Issue 3, pp. 108.e5-108.e13, (2015) (PubMed).

Ateeq, Kunju, Carskadon, Pandey, Singh, Pradeep, Tandon, Singhai, Goel, Amit, Agarwal, Dinda, Seth, Tsodikov, Chinnaiyan, Palanisamy: "Molecular profiling of ETS and non-ETS aberrations in prostate cancer patients from northern India." in: The Prostate, Vol. 75, Issue 10, pp. 1051-62, (2015) (PubMed).

Zhang, Wang, Hu, Wang, Yu, Wang: "The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line." in: Tumour biology, (2015) (PubMed).

Smith, Palanisamy, Zuhlke, Johnson, Siddiqui, Chinnaiyan, Kunju, Cooney, Tomlins: "HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular survey." in: The American journal of surgical pathology, Vol. 38, Issue 5, pp. 615-26, (2014) (PubMed).

Rink, Park, Volkmer, Xylinas, Hansen, Cha, Robinson, Hautmann, Küfer, Engel, Chun, Dahlem, Rubin, Shariat, Mosquera: "Loss of SPINK1 expression is associated with unfavorable outcomes in urothelial carcinoma of the bladder after radical cystectomy." in: Urologic oncology, Vol. 31, Issue 8, pp. 1716-24, (2013) (PubMed).

Bhalla, Kunju, Tomlins, Christopherson, Cortez, Carskadon, Siddiqui, Park, Mosquera, Pestano, Rubin, Chinnaiyan, Palanisamy: "Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 26, Issue 6, pp. 835-48, (2013) (PubMed).

Han, Mehra, Suleman, Tomlins, Wang, Singhal, Linetzky, Palanisamy, Zhou, Chinnaiyan, Shah: "Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 9, pp. 1176-85, (2009) (PubMed).

Tomlins, Rhodes, Yu, Varambally, Mehra, Perner, Demichelis, Helgeson, Laxman, Morris, Cao, Cao, Andrén, Fall, Johnson, Wei, Shah, Al-Ahmadie, Eastham, Eggener, Fine, Hotakainen, Stenman, Tsodikov et al.: "The role of SPINK1 in ETS rearrangement-negative prostate cancers. ..." in: Cancer cell, Vol. 13, Issue 6, pp. 519-28, (2008) (PubMed).

Target Details for SPINK1

Target: SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))

Alternative Name: SPINK1

Background: Full Gene Name: serine peptidase inhibitor, Kazal type 1
Synonyms: PCTT,PSTI,Spink3,TATI

Gene ID: 6690