YARS antibody (AA 1-528)

Catalog No. ABIN563694

Cited in 2+ publications. The Mouse Monoclonal anti-YARS antibody (Clone 2F3) (ABIN563694) specifically detects YARS in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for YARS antibody (AA 1-528) (ABIN563694)

Target: YARS (Yars) (Tyrosyl-tRNA Synthetase (Yars))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YARS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2F3

Product Details anti-YARS Antibody

Binding Specificity: AA 1-528

Purpose: Mouse monoclonal antibody raised against a full length recombinant YARS.

Sequence: MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS

Cross-Reactivity: Human, Mouse

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: YARS (AAH01933, 1 a.a. ~ 528 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-YARS antibody (ABIN563694)

Niehues, Bussmann, Steffes, Erdmann, Köhrer, Sun, Wagner, Schäfer, Wang, Koerdt, Stum, RajBhandary, Thomas, Aberle, Burgess, Yang, Dieterich, Storkebaum: "Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases." in: Nature communications, Vol. 6, pp. 7520, (2015) (PubMed).

Storkebaum, Leitão-Gonçalves, Godenschwege, Nangle, Mejia, Bosmans, Ooms, Jacobs, Van Dijck, Yang, Schimmel, Norga, Timmerman, Callaerts, Jordanova: "Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11782-7, (2009) (PubMed).

Target Details for YARS

Target: YARS (Yars) (Tyrosyl-tRNA Synthetase (Yars))

Alternative Name: YARS

Background: Full Gene Name: tyrosyl-tRNA synthetase
Synonyms: CMTDIC,TYRRS,YRS,YTS

Gene ID: 8565