CES2 antibody (AA 514-621)

Catalog No. ABIN563817

Cited in 2+ publications. The Mouse Monoclonal anti-CES2 antibody (Clone 4F12) (ABIN563817) specifically detects CES2 in WB, ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CES2 antibody (AA 514-621) (ABIN563817)

Target: CES2 (Carboxylesterase 2 (CES2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CES2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4F12

Product Details anti-CES2 Antibody

Binding Specificity: AA 514-621

Purpose: Mouse monoclonal antibody raised against a partial recombinant CES2.

Sequence: PPHMKADHGD ELPFVFRSFF GGNYIKFTEE EEQLSRKMMK YWANFARNGN PNGEGLPHWP LFDQEEQYLQ LNLQPAVGRA LKAHRLQFWK KALPQKIQEL EEPEERHT

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CES2 (NP_003860, 514 a.a. ~ 621 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CES2 antibody (ABIN563817)

Pratt, Durland-Busbice, Shepard, Heinz-Taheny, Iversen, Dantzig: "Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 5, pp. 1159-68, (2013) (PubMed).

Uchida, Otake, Tanaka, Hashimoto, Saigusa, Matsushita, Koike, Inoue, Ueeda, Okugawa, Inoue, Mohri, Kusunoki: "Clinical implications of CES2 RNA expression in neuroblastoma." in: Journal of pediatric surgery, Vol. 48, Issue 3, pp. 502-9, (2013) (PubMed).

Target Details for CES2

Target: CES2 (Carboxylesterase 2 (CES2))

Alternative Name: CES2

Background: Full Gene Name: carboxylesterase 2 (intestine, liver)
Synonyms: CE-2,CES2A1,PCE-2,iCE

Gene ID: 8824

NCBI Accession: NM_003869