OXSR1 antibody (AA 351-450)

Catalog No. ABIN564274

This Mouse Monoclonal antibody specifically detects OXSR1 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for OXSR1 antibody (AA 351-450) (ABIN564274)

Target: OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This OXSR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 5D5

Product Details anti-OXSR1 Antibody

Binding Specificity: AA 351-450

Purpose: Mouse monoclonal antibody raised against a partial recombinant OXSR1.

Sequence: KAAISQLRSP RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQIA TQPTQVSLPP TAEPAKTAQA LSSGSGSQET KIPISLVLRL RNSKKELNDI

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: OXSR1 (AAH08726.1, 351 a.a. ~ 450 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-OXSR1 antibody (ABIN564274)

Wakabayashi, Mori, Isobe, Sohara, Susa, Araki, Chiga, Kikuchi, Nomura, Mori, Matsuo, Murata, Nomura, Asano, Kawaguchi, Nonoyama, Rai, Sasaki, Uchida: "Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension." in: Cell reports, Vol. 3, Issue 3, pp. 858-68, (2013) (PubMed).

Trudu, Janas, Lanzani, Debaix, Schaeffer, Ikehata, Citterio, Demaretz, Trevisani, Ristagno, Glaudemans, Laghmani, DellAntonio, Loffing, Rastaldi, Manunta, Devuyst, Rampoldi: "Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression." in: Nature medicine, Vol. 19, Issue 12, pp. 1655-60, (2013) (PubMed).

Susa, Kita, Iwamoto, Yang, Lin, Ohta, Sohara, Rai, Sasaki, Alessi, Uchida: "Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels." in: Clinical and experimental nephrology, Vol. 16, Issue 4, pp. 530-8, (2012) (PubMed).

Susa, Sohara, Isobe, Chiga, Rai, Sasaki, Uchida: "WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone." in: Biochemical and biophysical research communications, Vol. 427, Issue 4, pp. 743-7, (2012) (PubMed).

Chiga, Rafiqi, Alessi, Sohara, Ohta, Rai, Sasaki, Uchida: "Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade." in: Journal of cell science, Vol. 124, Issue Pt 9, pp. 1391-5, (2011) (PubMed).

Target Details for OXSR1

Target: OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))

Alternative Name: OXSR1

Background: Full Gene Name: oxidative-stress responsive 1
Synonyms: KIAA1101,OSR1

Gene ID: 9943

Pathways: Tube Formation