PACSIN2 antibody (AA 342-371)

Catalog No. ABIN5647224

Product Details anti-PACSIN2 Antibody

Target: PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))

Binding Specificity: AA 342-371

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PACSIN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 342-371 from the human protein was used as the immunogen for the PACSIN2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Western blot: 1:500-1:1000,IHC (FFPE): 1:50-100,Immunofluorescence: 1:100

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PACSIN2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for PACSIN2

Target: PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))

Alternative Name: PACSIN2 (PACSIN2 Products)

Synonyms: zgc:77519 antibody, PACSIN2 antibody, DKFZp459J1025 antibody, SDPII antibody, AI197433 antibody, sdpii antibody, SdpII antibody, protein kinase C and casein kinase substrate in neurons 2 antibody, protein kinase C and casein kinase substrate in neurons 2 S homeolog antibody, pacsin2 antibody, PACSIN2 antibody, Pacsin2 antibody, pacsin2.S antibody

Background: Protein kinase C and casein kinase substrate in neurons protein 2 is a lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

UniProt: Q9UNF0