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KRIT1 antibody (AA 703-736)

KRIT1 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5647767
  • Target See all KRIT1 Antibodies
    KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
    Binding Specificity
    • 15
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 703-736
    Reactivity
    Human, Mouse, Rat
    Host
    • 35
    • 4
    Rabbit
    Clonality
    • 35
    • 4
    Polyclonal
    Conjugate
    • 16
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KRIT1 antibody is un-conjugated
    Application
    • 32
    • 17
    • 13
    • 13
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    Amino acids 703-736 (ENKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNS) from the human protein were used as the immunogen for the KRIT1 antibody.
    Isotype
    IgG
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    Discover our top product KRIT1 Primary Antibody
  • Application Notes
    Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the KRIT1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
    Alternative Name
    KRIT1 (KRIT1 Products)
    Background
    Krev interaction trapped protein 1 is a protein that in humans is encoded by the CCM1 gene. This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
    UniProt
    O00522
    Pathways
    Cell RedoxHomeostasis
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