RNF139 antibody (AA 565-664)

Catalog No. ABIN564886

This Mouse Polyclonal antibody specifically detects RNF139 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for RNF139 antibody (AA 565-664) (ABIN564886)

Target: RNF139 (Ring Finger Protein 139 (RNF139))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This RNF139 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RNF139 Antibody

Binding Specificity: AA 565-664

Purpose: Mouse polyclonal antibody raised against a partial recombinant RNF139.

Sequence: HYFHALCLRK WLYIQDTCPM CHQKVYIEDD IKDNSNVSNN NGFIPPNETP EEAVREAAAE SDRELNEDDS TDCDDDVQRE RNGVIQHTGA AAEEFNDDTD

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: RNF139 (NP_009149, 565 a.a. ~ 664 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-RNF139 antibody (ABIN564886)

Lee, Brauweiler, Rudolph, Hooper, Drabkin, Gemmill: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." in: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, (2010) (PubMed).

Irisawa, Inoue, Ozawa, Mori, Sato et al.: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, (2009) (PubMed).

Stagg, Thomas, van den Boomen, Wiertz, Drabkin, Gemmill, Lehner: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, (2009) (PubMed).

Brauweiler, Lorick, Lee, Tsai, Chan, Weissman, Drabkin, Gemmill: "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene." in: Oncogene, Vol. 26, Issue 16, pp. 2263-71, (2007) (PubMed).

Target Details for RNF139

Target: RNF139 (Ring Finger Protein 139 (RNF139))

Alternative Name: RNF139

Background: Full Gene Name: ring finger protein 139
Synonyms: HRCA1,MGC31961,RCA1,TRC8

Gene ID: 11236

NCBI Accession: NM_007218