SENP6 antibody (AA 1-110)

Catalog No. ABIN565219

This Mouse Monoclonal antibody specifically detects SENP6 in ELISA, WB and IHC (p). It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for SENP6 antibody (AA 1-110) (ABIN565219)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SENP6 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4B7

Product Details anti-SENP6 Antibody

Binding Specificity: AA 1-110

Purpose: Mouse monoclonal antibody raised against a partial recombinant SENP6.

Sequence: MAAGKSGGSA GEITFLEALA RSESKRDGGF KNNWSFDHEE ESEGDTDKDG TNLLSVDEDE DSETSKGKKL NRRSEIVANS SGEFILKTYV RRNKSESFKT LKGNPIGLNM

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: SENP6 (NP_056386, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-SENP6 antibody (ABIN565219)

Liu, Chen, Wang, Li, Wang: "Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6." in: PLoS pathogens, Vol. 9, Issue 6, pp. e1003480, (2013) (PubMed).

Dou, Huang, Singh, Carpenter, Yeh: "Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex." in: Molecular cell, Vol. 39, Issue 3, pp. 333-45, (2010) (PubMed).

Han, Huang, Sun, Xiang, Wang, Yeh, Chen, Li, Shi, Cang, Sun, Wang, Wang, Gao, Yi: "SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12906-15, (2010) (PubMed).

Target Details for SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Alternative Name: SENP6

Background: Full Gene Name: SUMO1/sentrin specific peptidase 6
Synonyms: FLJ11355,FLJ11887,KIAA0389,KIAA0797,SSP1,SUSP1

Gene ID: 26054

NCBI Accession: NM_015571