CNOT7 antibody (AA 1-285)

Catalog No. ABIN565426

This Mouse Monoclonal antibody specifically detects CNOT7 in WB, ELISA and IF. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for CNOT7 antibody (AA 1-285) (ABIN565426)

Target: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7 (CNOT7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CNOT7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 2F6

Product Details anti-CNOT7 Antibody

Binding Specificity: AA 1-285

Purpose: Mouse monoclonal antibody raised against a full length recombinant CNOT7.

Sequence: MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CNOT7 (AAH60852, 1 a.a. ~ 285 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CNOT7 antibody (ABIN565426)

Inoue, Morita, Hijikata, Fukuda-Yuzawa, Adachi, Isono, Ikawa, Kawamoto, Koseki, Natsume, Fukao, Ohara, Yamamoto, Kurosaki: "CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability." in: The Journal of experimental medicine, Vol. 212, Issue 9, pp. 1465-79, (2015) (PubMed).

Chekulaeva, Mathys, Zipprich, Attig, Colic, Parker, Filipowicz: "miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs." in: Nature structural & molecular biology, Vol. 18, Issue 11, pp. 1218-26, (2011) (PubMed).

Marchese, Aubareda, Tudor, Saklatvala, Clark, Dean: "MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27590-600, (2010) (PubMed).

Target Details for CNOT7

Target: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7 (CNOT7))

Alternative Name: CNOT7

Background: Full Gene Name: CCR4-NOT transcription complex, subunit 7
Synonyms: CAF1,hCAF-1

Gene ID: 29883

Pathways: Ribonucleoprotein Complex Subunit Organization