ABHD5 antibody (AA 1-349)

Catalog No. ABIN565526

Product Details anti-ABHD5 Antibody

Target: ABHD5 (Abhydrolase Domain Containing 5 (ABHD5))

Binding Specificity: AA 1-349

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABHD5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a full length recombinant ABHD5.

Sequence: MAAEEEEVDS ADTGERSGWL TGWLPTWCPT SISHLKEAEE KMLKCVPCTY KKEPVRISNG NKIWTLKFSH NISNKTPLVL LHGFGGGLGL WALNFGDLCT NRPVYAFDLL GFGRSSRPRF DSDAEEVENQ FVESIEEWRC ALGLDKMILL GHNLGGFLAA AYSLKYPSRV NHLILVEPWG FPERPDLADQ DRPIPVWIRA LGAALTPFNP LAGLRIAGPF GLSLVQRLRP DFKRKYSSMF EDDTVTEYIY HCNVQTPSGE TAFKNMTIPY GWAKRPMLQR IGKMHPDIPV SVIFGARSCI DGNSGTSIQS LRPHSYVKTI AILGAGHYVY ADQPEEFNQK VKEICDTVD

Cross-Reactivity: Human, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: ABHD5 (AAH21958, 1 a.a. ~ 349 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1F3

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-ABHD5 antibody (ABIN565526)

Hofer, Boeszoermenyi, Jaeger, Feiler, Arthanari, Mayer, Zehender, Rechberger, Oberer, Zimmermann, Lass, Haemmerle, Breinbauer, Zechner, Preiss-Landl: "Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling." in: The Journal of biological chemistry, Vol. 290, Issue 30, pp. 18438-53, (2015) (PubMed).

Kurtz, Peck, Fannin, Beysen, Miao, Landstreet, Ding, Turaga, Lund, Turner, Biddinger, Vickers, Sethupathy: "MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes." in: Diabetes, Vol. 63, Issue 9, pp. 3141-8, (2014) (PubMed).

Patel, Yang, Kozusko, Saudek, Savage: "Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 25, pp. 9163-8, (2014) (PubMed).

Camus, Schweiger, Herker, Harris, Kondratowicz, Tsou, Farese, Herath, Previs, Roddy, Pinto, Zechner, Ott et al.: "The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid ..." in: The Journal of biological chemistry, Vol. 289, Issue 52, pp. 35770-80, (2014) (PubMed).

Pollak, Schweiger, Jaeger, Kolb, Kumari, Schreiber, Kolleritsch, Markolin, Grabner, Heier, Zierler, Rülicke, Zimmermann, Lass, Zechner, Haemmerle: "Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier." in: Journal of lipid research, Vol. 54, Issue 4, pp. 1092-102, (2013) (PubMed).

Guo, Ma, Kadegowda, Betters, Xie, Liu, Liu, Miao, Ou, Su, Zheng, Xue, Shi, Yu: "Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice." in: Journal of lipid research, Vol. 54, Issue 8, pp. 2109-20, (2013) (PubMed).

Louche, Badin, Montastier, Laurens, Bourlier, de Glisezinski, Thalamas, Viguerie, Langin, Moro: "Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects." in: The Journal of clinical endocrinology and metabolism, Vol. 98, Issue 12, pp. 4863-71, (2013) (PubMed).

Inoue, Kobayashi, Inoguchi, Sonoda, Maeda, Hirata, Fujimura, Miura, Hirano, Takayanagi: "Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice." in: Biochemical and biophysical research communications, Vol. 438, Issue 1, pp. 224-9, (2013) (PubMed).

Grall, Guaguère, Planchais, Grond, Bourrat, Hausser, Hitte, Le Gallo, Derbois, Kim, Lagoutte, Degorce-Rubiales, Radner, Thomas, Küry, Bensignor, Fontaine, Pin, Zimmermann, Zechner, Lathrop, Galibert et al.: "PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. ..." in: Nature genetics, Vol. 44, Issue 2, pp. 140-7, (2012) (PubMed).

Stenson, Rydén, Venteclef, Dahlman, Pettersson, Mairal, Aström, Blomqvist, Wang, Jocken, Clément, Langin, Arner, Laurencikiene: "Liver X receptor (LXR) regulates human adipocyte lipolysis." in: The Journal of biological chemistry, Vol. 286, Issue 1, pp. 370-9, (2011) (PubMed).

Kinney, Qiao, Levaugh, Shao: "B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice." in: Endocrinology, Vol. 151, Issue 8, pp. 3624-32, (2010) (PubMed).

Target Details for ABHD5

Target: ABHD5 (Abhydrolase Domain Containing 5 (ABHD5))

Alternative Name: ABHD5 (ABHD5 Products)

Background: Full Gene Name: abhydrolase domain containing 5
Synonyms: CDS,CGI58,IECN2,MGC8731,NCIE2

Gene ID: 51099

Pathways: Lipid Metabolism