Recombinant Complement Receptor 1 & 2 antibody

Catalog No. ABIN5668017

This Rabbit Chimeric antibody specifically detects Complement Receptor 1 & 2 in FACS, IP, WB, BR, CoSt and IHC (fro). It exhibits reactivity toward Mouse.

Quick Overview for Recombinant Complement Receptor 1 & 2 antibody (ABIN5668017)

Target: Complement Receptor 1 & 2

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Chimeric

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Blocking Reagent (BR), Co-Stimulation (CoSt), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 7G6

Product Details

Purpose: Anti-Complement Receptor 1 & 2 [7G6], Rabbit IgG, kappa

Specificity: Recognises an epitope shared by 145-150 kDa and 190 kDa complement receptor proteins, originally designated CR2 (CD21) and CR1 (CD35).

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2b

Purification: Protein A affinity purified

Immunogen: Purified Mouse CR1.

Isotype: IgG kappa

Application Details

Application Notes: This antibody binds mouse complement receptors CR1 and CR2, functionally blocking CR2 leading to suppression of a normal antibody immune response (see Heyman et al. 1990, PMID: 1695671)

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details

Target: Complement Receptor 1 & 2

Background: CD21 & CD35

UniProt: P19070, P17927