CERS6 antibody (AA 62-131)

Catalog No. ABIN566978

The Mouse Polyclonal anti-CERS6 antibody has been validated for ELISA and WB. It is suitable to detect CERS6 in samples from Human. There are 9+ publications available.

Quick Overview for CERS6 antibody (AA 62-131) (ABIN566978)

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This CERS6 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-CERS6 Antibody

Binding Specificity: AA 62-131

Purpose: Mouse polyclonal antibody raised against a partial recombinant LASS6.

Sequence: PCAIALNIQA NGPQIAPPNA ILEKVFTAIT KHPDEKRLEG LSKQLDWDVR SIQRWFRQRR NQEKPSTLTR

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CERS6 antibody (ABIN566978)

Schüll, Günther, Brodesser, Seeger, Tosetti, Wiegmann, Pongratz, Diaz, Witt, Andree, Brinkmann, Krönke, Wiesner, Kashkar: "Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6." in: Cell death & disease, Vol. 6, pp. e1691, (2015) (PubMed).

Cheng, Bai, Beckham, Marrison, Yount, Young, Lu, Bartlett, Wu, Keane, Armeson, Marshall, Keane, Smith, Jones, Drake, Bielawska, Norris, Liu: "Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse." in: The Journal of clinical investigation, Vol. 123, Issue 10, pp. 4344-58, (2013) (PubMed).

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells." in: Anticancer research, Vol. 32, Issue 3, pp. 753-60, (2012) (PubMed).

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy." in: Anticancer research, Vol. 32, Issue 7, pp. 2479-85, (2012) (PubMed).

Senkal, Ponnusamy, Manevich, Meyers-Needham, Saddoughi, Mukhopadyay, Dent, Bielawski, Ogretmen et al.: "Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi ..." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 42446-58, (2011) (PubMed).

Senkal, Ponnusamy, Bielawski, Hannun, Ogretmen: "Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 1, pp. 296-308, (2010) (PubMed).

White-Gilbertson, Mullen, Senkal, Lu, Ogretmen, Obeid, Voelkel-Johnson: "Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells." in: Oncogene, Vol. 28, Issue 8, pp. 1132-41, (2009) (PubMed).

Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: "Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas." in: Molecular cancer therapeutics, Vol. 6, Issue 2, pp. 712-22, (2007) (PubMed).

Yu, Novgorodov, Chudakova, Zhu, Bielawska, Bielawski, Obeid, Kindy, Gudz: "JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction." in: The Journal of biological chemistry, Vol. 282, Issue 35, pp. 25940-9, (2007) (PubMed).

Target Details for CERS6

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Alternative Name: LASS6

Background: Full Gene Name: LAG1 homolog, ceramide synthase 6
Synonyms: CerS6,MGC129949,MGC129950

Gene ID: 253782

NCBI Accession: NM_203463