PRUNE2 antibody (C-Term)

Catalog No. ABIN5671800

The Rabbit Polyclonal anti-PRUNE2 antibody has been validated for WB. It is suitable to detect PRUNE2 in samples from Human.

Quick Overview for PRUNE2 antibody (C-Term) (ABIN5671800)

Target: PRUNE2 (Prune Homolog 2 (PRUNE2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRUNE2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRUNE2 Antibody

Binding Specificity: C-Term

Sequence: LNDTHPRRIK LTAPNINLSL DQSEGSILSD DNLDSPDEID INVDELDTPD

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PRUNE2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRUNE2

Target: PRUNE2 (Prune Homolog 2 (PRUNE2))

Alternative Name: PRUNE2

Background: The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants.

Alias Symbols: BMCC1, BNIPXL, C9orf65, KIAA0367

Protein Size: 352

Gene ID: 158471

NCBI Accession: NM_001308047, NP_001294976