Ubiquitin B antibody (C-Term)

Catalog No. ABIN5671946

This Rabbit Polyclonal antibody specifically detects Ubiquitin B in WB. It exhibits reactivity toward Human.

Quick Overview for Ubiquitin B antibody (C-Term) (ABIN5671946)

Target: Ubiquitin B (UBB)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ubiquitin B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Ubiquitin B Antibody

Binding Specificity: C-Term

Sequence: LIFAGKQLED GRTLSDYNIQ KESTLHLVLR LRGGMQIFVK TLTGKTITLE

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human UBB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ubiquitin B

Target: Ubiquitin B (UBB)

Alternative Name: UBB

Background: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.

Alias Symbols: HEL-S-50

Protein Size: 229

Gene ID: 7314

NCBI Accession: NM_001281716, NP_001268645

UniProt: P0CG47

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, Autophagy, EGFR Downregulation, Ubiquitin Proteasome Pathway