TAF4 antibody (N-Term)

Catalog No. ABIN7487377

The Rabbit Polyclonal anti-TAF4 antibody (ABIN7487377) specifically detects TAF4 in WB. The antibody is reactive with Human samples.

Quick Overview for TAF4 antibody (N-Term) (ABIN7487377)

Target: TAF4 (TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAF4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TAF4 Antibody

Binding Specificity: N-Term

Sequence: AGAAGAGPAA PAEGAPGAAP EPPPAGRARP GGGGPQRPGP PSPRRPLVPA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TAF4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TAF4

Target: TAF4 (TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4))

Alternative Name: TAF4

Background: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.

Alias Symbols: TAF2C, TAF4A, TAF2C1, TAFII130, TAFII135

Protein Size: 1085

Gene ID: 6874

NCBI Accession: NM_003185, NP_003176

UniProt: O00268