TDRKH antibody (C-Term)

Catalog No. ABIN5673744

This Rabbit Polyclonal antibody specifically detects TDRKH in WB. It exhibits reactivity toward Human.

Quick Overview for TDRKH antibody (C-Term) (ABIN5673744)

Target: TDRKH (Tudor and KH Domain Containing (TDRKH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDRKH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TDRKH Antibody

Binding Specificity: C-Term

Sequence: DMATETDASL STLLTETKKS SGEITHTLSC LSLSEAASMS GDDNLEDDYL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TDRKH

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TDRKH

Target: TDRKH (Tudor and KH Domain Containing (TDRKH))

Alternative Name: TDRKH

Background: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.

Alias Symbols: TDRD2

Protein Size: 561

Gene ID: 11022

NCBI Accession: NM_001083963, NP_001077432

UniProt: Q9Y2W6