TEN1 antibody (N-Term)

Catalog No. ABIN5673933

This Rabbit Polyclonal antibody specifically detects TEN1 in WB. It exhibits reactivity toward Mouse.

Quick Overview for TEN1 antibody (N-Term) (ABIN5673933)

Target: TEN1 (TEN1 Telomerase Capping Complex Subunit (TEN1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details anti-TEN1 Antibody

Binding Specificity: N-Term

Sequence: GSTLRTFGRL YLYDMARSLM TLAAPQKPDQ CQLLVCTNLV EPFEAHVNFL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of Mouse TEN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TEN1

Target: TEN1 (TEN1 Telomerase Capping Complex Subunit (TEN1))

Alternative Name: TEN1

Background: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis, it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage, seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (By similarity).

Alias Symbols: 2310004N24Rik

Protein Size: 161

Gene ID: 69535

NCBI Accession: NM_027107, NP_081383

UniProt: Q9D7K2