PODXL antibody (AA 351-450)

Catalog No. ABIN5675332

The Rabbit Polyclonal anti-PODXL antibody has been validated for WB and ELISA. It is suitable to detect PODXL in samples from Mouse.

Quick Overview for PODXL antibody (AA 351-450) (ABIN5675332)

Target: PODXL (Podocalyxin-Like (PODXL))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PODXL antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PODXL Antibody

Binding Specificity: AA 351-450

Cross-Reactivity: Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse PODXL

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PODXL

Target: PODXL (Podocalyxin-Like (PODXL))

Alternative Name: PODXL,

Background:

Synonyms: Podocalyxin, Podxl, Podocalyxin-like protein 1, PC, PCLP-1, Pclp1

Background: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Gene ID: 27205

UniProt: Q9R0M4

Pathways: Tube Formation