PODXL antibody (AA 351-450) (Biotin)

Catalog No. ABIN5675333

This anti-PODXL antibody is a Rabbit Polyclonal antibody detecting PODXL in WB and ELISA. Suitable for Mouse.

Quick Overview for PODXL antibody (AA 351-450) (Biotin) (ABIN5675333)

Target: PODXL (Podocalyxin-Like (PODXL))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PODXL antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Product Details anti-PODXL Antibody (Biotin)

Binding Specificity: AA 351-450

Cross-Reactivity: Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse PODXL

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PODXL

Target: PODXL (Podocalyxin-Like (PODXL))

Alternative Name: PODXL,

Background:

Synonyms: Podocalyxin, Podxl, Podocalyxin-like protein 1, PC, PCLP-1, Pclp1

Background: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Gene ID: 27205

UniProt: Q9R0M4

Pathways: Tube Formation