KLHDC8B antibody (AA 201-300) (HRP)

Catalog No. ABIN5675548

The Rabbit Polyclonal anti-KLHDC8B antibody has been validated for WB, ELISA, IHC (fro) and IHC (p). It is suitable to detect KLHDC8B in samples from Human.

Quick Overview for KLHDC8B antibody (AA 201-300) (HRP) (ABIN5675548)

Target: KLHDC8B (Kelch Domain Containing 8B (KLHDC8B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHDC8B antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KLHDC8B Antibody (HRP)

Binding Specificity: AA 201-300

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KLHDC8B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KLHDC8B

Target: KLHDC8B (Kelch Domain Containing 8B (KLHDC8B))

Alternative Name: KLHDC8B

Background:

Synonyms: FLJ11302, FP17659, Kelch domain containing 8B, Kelch domain containing protein 8B, Kelch domain-containing protein 8B, KLD8B_HUMAN, Klhdc8b, MGC35097, MGC94736.

Background: Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).

Gene ID: 200942

UniProt: Q8IXV7