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BUB1B antibody

BUB1B Reactivity: Human WB, IF, IP Host: Mouse Monoclonal 8G1 unconjugated
Catalog No. ABIN567606
  • Target See all BUB1B Antibodies
    BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))
    Reactivity
    • 71
    • 35
    • 14
    • 3
    • 1
    Human
    Host
    • 54
    • 17
    • 4
    Mouse
    Clonality
    • 54
    • 21
    Monoclonal
    Conjugate
    • 46
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BUB1B antibody is un-conjugated
    Application
    • 61
    • 25
    • 24
    • 22
    • 14
    • 12
    • 12
    • 10
    • 9
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Specificity
    This antibody reacts with BUBR1 (121 kDa) on Western blotting, Immunoprecipitation and Immunocytochemistry.
    Purification
    Protein-A Agarose Chromatography of hybridoma supernatant.
    Clone
    8G1
    Isotype
    IgG1
    Top Product
    Discover our top product BUB1B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.2 containing 50 % Glycerol without preservatives.
    Preservative
    Without preservative
  • Target
    BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))
    Alternative Name
    BUB1B (BUB1B Products)
    Background
    Metaphase checkpoint controls sense abnormalities in chromosome alignment during mitosis and prevent progression to anaphase until proper alignment has been attained. A number of proteins, including Mitotic arrest deficiency protein 2 (MAD2), Budding uninhibited benzimidazole 1 (BUB1) and Budding uninhibited benzimidazole receptor 1 (BUBR1), have been implicated in the metaphase checkpoint control in mammalian cells. BUB1 and BUBR1 both localize to kinetochores during mitosis, suggesting that they play a role in delaying anaphase until all chromosomes achieve correct, bipolar attachment to the spindle. BUB1 and BUBR1 respond differently to spindle dynamics, they are part of a common complex during mitosis and BUB1 and BUBR1 may integrate different 'spindle assembly signals' into a single signal which can then be interpreted by downstream cell cycle regulators.Synonyms: BUB1 beta, BUBR1, MAD3/BUB1-related protein kinase, MAD3L, Mitotic checkpoint kinase MAD3L, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Protein SSK1
    Gene ID
    701
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